The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas

Here, we report that kinase-dead IKKα knock-in mice develop spontaneous lung squamous cell carcinomas (SCCs) associated with IKKα downregulation and marked pulmonary inflammation. IKKα reduction upregulated the expression of p63, Trim29, and keratin 5 (K5), which serve as diagnostic markers for huma...

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Autori principali: Xiao, Zouxiang, Jiang, Qun, Willette-Brown, Jami, Xi, Sichuan, Zhu, Feng, Burkett, Sandra, Back, Timothy, Song, Na-Young, Datla, Mahesh, Sun, Zhonghe, Goldszmid, Romina, Lin, Fanching, Cohoon, Travis, Pike, Kristen, Wu, Xiaolin, Schrump, David S., Wong, Kwok-Kin, Young, Howard A., Trinchieri, Giorgio, Wiltrout, Robert H., Hu, Yinling
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649010/
https://ncbi.nlm.nih.gov/pubmed/23597566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.03.009
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