An integrative functional genomics framework for effective identification of novel regulatory variants in genome–phenome studies

BACKGROUND: Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear. A comprehensive investigation of regulatory mechanisms and the gene regulatory networks between phenome-wide associa...

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Veröffentlicht in:Genome Med
Hauptverfasser: Zhao, Junfei, Cheng, Feixiong, Jia, Peilin, Cox, Nancy, Denny, Joshua C., Zhao, Zhongming
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789733/
https://ncbi.nlm.nih.gov/pubmed/29378629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0513-x
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