Large-scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets

Here, we present a large (N=107,207) genome-wide association study (GWAS) of general cognitive ability (g), further enhanced by combining results with a large-scale GWAS of educational attainment. We identified 70 independent genomic loci associated with GCA. Results showed significant enrichment fo...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Lam, Max, Trampush, Joey W., Yu, Jin, Knowles, Emma, Davies, Gail, Liewald, David C., Starr, John M., Djurovic, Srdjan, Melle, Ingrid, Sundet, Kjetil, Christoforou, Andrea, Reinvang, Ivar, DeRosse, Pamela, Lundervold, Astri J., Steen, Vidar M., Espeseth, Thomas, Räikkönen, Katri, Widen, Elisabeth, Palotie, Aarno, Eriksson, Johan G., Giegling, Ina, Konte, Bettina, Roussos, Panos, Giakoumaki, Stella, Burdick, Katherine E., Payton, Antony, Ollier, William, Chiba-Falek, Ornit, Attix, Deborah K., Need, Anna C., Cirulli, Elizabeth T., Voineskos, Aristotle N., Stefanis, Nikos C., Avramopoulos, Dimitrios, Hatzimanolis, Alex, Arking, Dan E., Smyrnis, Nikolaos, Bilder, Robert M., Freimer, Nelson A., Cannon, Tyrone D., London, Edythe, Poldrack, Russell A., Sabb, Fred W., Congdon, Eliza, Conley, Emily Drabant, Scult, Matthew A., Dickinson, Dwight, Straub, Richard E., Donohoe, Gary, Morris, Derek, Corvin, Aiden, Gill, Michael, Hariri, Ahmad R., Weinberger, Daniel R., Pendleton, Neil, Bitsios, Panos, Rujescu, Dan, Lahti, Jari, Le Hellard, Stephanie, Keller, Matthew C., Andreassen, Ole A., Deary, Ian J., Glahn, David C., Malhotra, Anil K., Lencz, Todd
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789458/
https://ncbi.nlm.nih.gov/pubmed/29186694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.11.028
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