Large-scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets

Here, we present a large (N=107,207) genome-wide association study (GWAS) of general cognitive ability (g), further enhanced by combining results with a large-scale GWAS of educational attainment. We identified 70 independent genomic loci associated with GCA. Results showed significant enrichment fo...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Cell Rep
Κύριοι συγγραφείς: Lam, Max, Trampush, Joey W., Yu, Jin, Knowles, Emma, Davies, Gail, Liewald, David C., Starr, John M., Djurovic, Srdjan, Melle, Ingrid, Sundet, Kjetil, Christoforou, Andrea, Reinvang, Ivar, DeRosse, Pamela, Lundervold, Astri J., Steen, Vidar M., Espeseth, Thomas, Räikkönen, Katri, Widen, Elisabeth, Palotie, Aarno, Eriksson, Johan G., Giegling, Ina, Konte, Bettina, Roussos, Panos, Giakoumaki, Stella, Burdick, Katherine E., Payton, Antony, Ollier, William, Chiba-Falek, Ornit, Attix, Deborah K., Need, Anna C., Cirulli, Elizabeth T., Voineskos, Aristotle N., Stefanis, Nikos C., Avramopoulos, Dimitrios, Hatzimanolis, Alex, Arking, Dan E., Smyrnis, Nikolaos, Bilder, Robert M., Freimer, Nelson A., Cannon, Tyrone D., London, Edythe, Poldrack, Russell A., Sabb, Fred W., Congdon, Eliza, Conley, Emily Drabant, Scult, Matthew A., Dickinson, Dwight, Straub, Richard E., Donohoe, Gary, Morris, Derek, Corvin, Aiden, Gill, Michael, Hariri, Ahmad R., Weinberger, Daniel R., Pendleton, Neil, Bitsios, Panos, Rujescu, Dan, Lahti, Jari, Le Hellard, Stephanie, Keller, Matthew C., Andreassen, Ole A., Deary, Ian J., Glahn, David C., Malhotra, Anil K., Lencz, Todd
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2017
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789458/
https://ncbi.nlm.nih.gov/pubmed/29186694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.11.028
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