Brain-derived neurotrophic factor in the mesolimbic reward circuitry mediates nociception in chronic neuropathic pain

BACKGROUND: The mesolimbic reward system plays a critical role in modulating nociception; however, its underlying molecular, cellular, and neural circuitry mechanisms remain unknown. METHODS: Chronic constrictive injury (CCI) of the sciatic nerve was used to model neuropathic pain. Projection-specif...

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Publicat a:Biol Psychiatry
Autors principals: Zhang, Hongxing, Qian, Yi-Ling, Li, Chen, Liu, Di, Wang, Lei, Wang, Xiao-Yi, Liu, Mei-Jun, Liu, He, Zhang, Song, Guo, Xiao-Yun, Yang, Jun-Xia, Ding, Hai-Lei, Koo, Ja Wook, Mouzon, Ezekiell, Deisseroth, Karl, Nestler, Eric J, Zachariou, Venetia, Han, Ming-Hu, Cao, Jun-Li
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788809/
https://ncbi.nlm.nih.gov/pubmed/28390647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2017.02.1180
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