Human brain imaging of nicotinic acetylcholine α4β2* receptors using [(18)F]Nifene: Selectivity, functional activity, toxicity, aging effects, gender effects, and extrathalamic pathways

Nicotinic acetylcholinergic receptors (nAChR’s) have been implicated in several brain disorders, including addiction, Parkinson’s disease, Alzheimer’s disease and schizophrenia. Here we report in vitro selectivity and functional properties, toxicity in rats, in vivo evaluation in humans, and compari...

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Detaylı Bibliyografya
Yayımlandı:J Comp Neurol
Asıl Yazarlar: Mukherjee, Jogeshwar, Lao, Patrick J., Betthauser, Tobey J., Samra, Gurleen K., Pan, Min-Liang, Patel, Ishani H., Liang, Christopher, Metherate, Raju, Christian, Bradley T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788574/
https://ncbi.nlm.nih.gov/pubmed/28875553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cne.24320
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