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Targeting DNA hypermethylation: Computational modeling of DNA demethylation treatment of acute myeloid leukemia
In acute myeloid leukemia (AML) DNA hypermethylation of gene promoters is frequently observed and often correlates with a block of differentiation. Treatment of AML patients with DNA methyltransferase inhibitors results in global hypomethylation of genes and, thereby, can lead to a reactivation of t...
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| Pubblicato in: | Epigenetics |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5788435/ https://ncbi.nlm.nih.gov/pubmed/28758855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2017.1361090 |
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