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ATM-mediated mitochondrial damage response triggered by nuclear DNA damage in normal human lung fibroblasts

Ionizing radiation (IR) elevates mitochondrial oxidative phosphorylation (OXPHOS) in response to the energy requirement for DNA damage responses. Reactive oxygen species (ROS) released during mitochondrial OXPHOS may cause oxidative damage to mitochondria in irradiated cells. In this paper, we inves...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Shimura, Tsutomu, Sasatani, Megumi, Kawai, Hidehiko, Kamiya, Kenji, Kobayashi, Junya, Komatsu, Kenshi, Kunugita, Naoki
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788412/
https://ncbi.nlm.nih.gov/pubmed/29099268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1387697
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