In Vitro, In Silico, and In Vivo Analyses of Novel Aromatic Amidines against Trypanosoma cruzi

Five bis-arylimidamides were assayed as anti-Trypanosoma cruzi agents by in vitro, in silico, and in vivo approaches. None were considered to be pan-assay interference compounds. They had a favorable pharmacokinetic landscape and were active against trypomastigotes and intracellular forms, and in co...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Santos, Camila C., Lionel, Jéssica R., Peres, Raiza B., Batista, Marcos M., da Silva, Patrícia B., de Oliveira, Gabriel M., da Silva, Cristiane F., Batista, Denise G. J., Souza, Sandra Maria O., Andrade, Carolina H., Neves, Bruno J., Braga, Rodolpho C., Patrick, Donald A., Bakunova, Svetlana M., Tidwell, Richard R., Soeiro, Maria de Nazaré C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786784/
https://ncbi.nlm.nih.gov/pubmed/29203486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02205-17
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