Highly Sensitive Detection of Isoniazid Heteroresistance in Mycobacterium tuberculosis by DeepMelt Assay

Detection of heteroresistance of Mycobacterium tuberculosis remains challenging using current genotypic drug susceptibility testing methods. Here, we described a melting curve analysis-based approach, termed DeepMelt, that can detect less-abundant mutants through selective clamping of the wild type...

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Vydáno v:J Clin Microbiol
Hlavní autoři: Liang, Bin, Tan, Yaoju, Li, Zi, Tian, Xueshan, Du, Chen, Li, Hui, Li, Guoli, Yao, Xiangyang, Wang, Zhongan, Xu, Ye, Li, Qingge
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Mycobacteriology and Aerobic Actinomycetes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786724/
https://ncbi.nlm.nih.gov/pubmed/29118176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.01239-17
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