GSK-3 inhibition overcomes chemoresistance in human breast cancer

Glycogen Synthase Kinase-3β (GSK-3β), a serine/threonine protein kinase, is an emerging therapeutic target in the treatment of human breast cancer. In this study, we demonstrate that the pharmacological inhibition of GSK-3 by two novel small molecule GSK-3 inhibitors, 9-ING-41 and 9-ING-87, reduced...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Ugolkov, Andrey, Gaisina, Irina, Zhang, Jin-San, Billadeau, Daniel D., White, Kevin, Kozikowski, Alan, Jain, Sarika, Cristofanilli, Massimo, Giles, Francis, O’Halloran, Thomas, Cryns, Vincent L., Mazar, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786372/
https://ncbi.nlm.nih.gov/pubmed/27424289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2016.07.006
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