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Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme
Site-directed RNA editing (SDRE) is a general strategy for making targeted base changes in RNA molecules. Although the approach is relatively new, several groups, including our own, have been working on its development. The basic strategy has been to couple the catalytic domain of an adenosine (A) t...
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| Publicado en: | RNA Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Taylor & Francis
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5786015/ https://ncbi.nlm.nih.gov/pubmed/29099293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2017.1387711 |
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