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Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme

Site-directed RNA editing (SDRE) is a general strategy for making targeted base changes in RNA molecules. Although the approach is relatively new, several groups, including our own, have been working on its development. The basic strategy has been to couple the catalytic domain of an adenosine (A) t...

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Vallecillo-Viejo, Isabel C., Liscovitch-Brauer, Noa, Montiel-Gonzalez, Maria Fernanda, Eisenberg, Eli, Rosenthal, Joshua J. C.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786015/
https://ncbi.nlm.nih.gov/pubmed/29099293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2017.1387711
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