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Restrained management of copper level enhances the antineoplastic activity of imatinib in vitro and in vivo

The present study was designed to investigate if elevated copper level can be targeted to enhance the efficacy of a significant anticancer drug, imatinib (ITB). The antineoplastic activity of this drug was assessed in the HepG2, HEK-293, MCF-7 and MDA-MD-231 cells targeting elevated copper level as...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hassan, Iftekhar, Khan, Azmat Ali, Aman, Shazia, Qamar, Wajhul, Ebaid, Hossam, Al-Tamimi, Jameel, Alhazza, Ibrahim M., Rady, Ahmed M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786010/
https://ncbi.nlm.nih.gov/pubmed/29374195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19410-1
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