OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity

Paclitaxel is among the most widely used anticancer drugs and is known to cause a dose-limiting peripheral neurotoxicity, the initiating mechanisms of which remain unknown. Here, we identified the murine solute carrier organic anion–transporting polypeptide B2 (OATP1B2) as a mediator of paclitaxel-i...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Leblanc, Alix F., Sprowl, Jason A., Alberti, Paola, Chiorazzi, Alessia, Arnold, W. David, Gibson, Alice A., Hong, Kristen W., Pioso, Marissa S., Chen, Mingqing, Huang, Kevin M., Chodisetty, Vamsi, Costa, Olivia, Florea, Tatiana, de Bruijn, Peter, Mathijssen, Ron H., Reinbolt, Raquel E., Lustberg, Maryam B., Sucheston-Campbell, Lara E., Cavaletti, Guido, Sparreboom, Alex, Hu, Shuiying
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785270/
https://ncbi.nlm.nih.gov/pubmed/29337310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96160
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