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A double negative: inhibition of hepatic G(i) signaling improves glucose homeostasis
Hepatic glucose production (HGP) is a key determinant of glucose homeostasis. Glucagon binding to its cognate seven-transmembrane G(s)-coupled receptor in hepatocytes stimulates cAMP production, resulting in increased HGP. In this issue of the JCI, Rossi and colleagues tested the hypothesis that act...
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| Publicado no: | J Clin Invest |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5785259/ https://ncbi.nlm.nih.gov/pubmed/29337307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99037 |
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