Hepatic G(i) signaling regulates whole-body glucose homeostasis

An increase in hepatic glucose production (HGP) is a key feature of type 2 diabetes. Excessive signaling through hepatic G(s)–linked glucagon receptors critically contributes to pathologically elevated HGP. Here, we tested the hypothesis that this metabolic impairment can be counteracted by enhancin...

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書誌詳細
出版年:J Clin Invest
主要な著者: Rossi, Mario, Zhu, Lu, McMillin, Sara M., Pydi, Sai Prasad, Jain, Shanu, Wang, Lei, Cui, Yinghong, Lee, Regina J., Cohen, Amanda H., Kaneto, Hideaki, Birnbaum, Morris J., Ma, Yanling, Rotman, Yaron, Liu, Jie, Cyphert, Travis J., Finkel, Toren, McGuinness, Owen P., Wess, Jürgen
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2018
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785257/
https://ncbi.nlm.nih.gov/pubmed/29337301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94505
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