Hepatic G(i) signaling regulates whole-body glucose homeostasis

An increase in hepatic glucose production (HGP) is a key feature of type 2 diabetes. Excessive signaling through hepatic G(s)–linked glucagon receptors critically contributes to pathologically elevated HGP. Here, we tested the hypothesis that this metabolic impairment can be counteracted by enhancin...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Rossi, Mario, Zhu, Lu, McMillin, Sara M., Pydi, Sai Prasad, Jain, Shanu, Wang, Lei, Cui, Yinghong, Lee, Regina J., Cohen, Amanda H., Kaneto, Hideaki, Birnbaum, Morris J., Ma, Yanling, Rotman, Yaron, Liu, Jie, Cyphert, Travis J., Finkel, Toren, McGuinness, Owen P., Wess, Jürgen
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2018
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785257/
https://ncbi.nlm.nih.gov/pubmed/29337301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94505
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