PD-L1 on host cells is essential for PD-L1 blockade–mediated tumor regression

Programmed death–ligand 1 (PD-L1) expression on tumor cells is essential for T cell impairment, and PD-L1 blockade therapy has shown unprecedented durable responses in several clinical studies. Although higher expression of PD-L1 on tumor cells is associated with a better immune response after Ab bl...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Tang, Haidong, Liang, Yong, Anders, Robert A., Taube, Janis M., Qiu, Xiangyan, Mulgaonkar, Aditi, Liu, Xin, Harrington, Susan M., Guo, Jingya, Xin, Yangchun, Xiong, Yahong, Nham, Kien, Silvers, William, Hao, Guiyang, Sun, Xiankai, Chen, Mingyi, Hannan, Raquibul, Qiao, Jian, Dong, Haidong, Peng, Hua, Fu, Yang-Xin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785245/
https://ncbi.nlm.nih.gov/pubmed/29337303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96061
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