Enhanced clinical-scale manufacturing of TCR transduced T-cells using closed culture system modules

BACKGROUND: Genetic engineering of T-cells to express specific T cell receptors (TCR) has emerged as a novel strategy to treat various malignancies. More widespread utilization of these types of therapies has been somewhat constrained by the lack of closed culture processes capable of expanding suff...

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Detalles Bibliográficos
Publicado en:J Transl Med
Main Authors: Jin, Jianjian, Gkitsas, Nikolaos, Fellowes, Vicki S., Ren, Jiaqiang, Feldman, Steven A., Hinrichs, Christian S., Stroncek, David F., Highfill, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2018
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784598/
https://ncbi.nlm.nih.gov/pubmed/29368612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1384-z
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