Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells

BACKGROUND: Clinical trials of Chimeric Antigen Receptor (CAR) T cells manufactured from autologous peripheral blood mononuclear cell (PBMC) concentrates for the treatment of hematologic malignancies have been promising, but CAR T cell yields have been variable. This variability is due in part to th...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Stroncek, David F., Lee, Daniel W., Ren, Jiaqiang, Sabatino, Marianna, Highfill, Steven, Khuu, Hanh, Shah, Nirali N., Kaplan, Rosandra N., Fry, Terry J., Mackall, Crystal L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353875/
https://ncbi.nlm.nih.gov/pubmed/28298232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1160-5
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