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Autologous Lymphapheresis for the Production of Chimeric Antigen Receptor (CAR) T Cells

BACKGROUND: Chimeric antigen receptor (CAR) T cells are a promising new immunotherapy. The first step in manufacturing is to collect autologous CD3+ lymphocytes by apheresis. Patients, however, are often leukopenic or have other disease-related complications. We evaluated the feasibility of collecti...

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Detalhes bibliográficos
Publicado no:Transfusion
Main Authors: Allen, Elizabeth S., Stroncek, David F., Ren, Jiaqiang, Eder, Anne F., West, Kamille A., Fry, Terry J., Lee, Daniel W., Mackall, Crystal L., Conry-Cantilena, Cathy
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5398918/
https://ncbi.nlm.nih.gov/pubmed/28236305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/trf.14003
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