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PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway

BACKGROUND: Protein kinase N2 (PKN2) is a PKC-related serine/threonine-protein kinase. PKN2 is required for tumor cell migration, invasion and apoptosis. However, the functional role of PKN2 in regulating tumor associated macrophages (TAMs) polarization in colon cancer has never been reported. METHO...

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Bibliografske podrobnosti
izdano v:Mol Cancer
Main Authors: Cheng, Yang, Zhu, Yun, Xu, Jiajia, Yang, Min, Chen, Peiyu, Xu, Wanfu, Zhao, Junhong, Geng, Lanlan, Gong, Sitang
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784528/
https://ncbi.nlm.nih.gov/pubmed/29368606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-017-0747-z
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