Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer

Tumor-associated macrophages (TAM) are prominent components of tumor microenvironment (TME) and capable of promoting cancer progression. However, the mechanisms for the formation of M2-like TAMs remain enigmatic. Here, we show that lactate is a pivotal oncometabolite in the TME that drives macrophag...

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Vydáno v:Cell Cycle
Hlavní autoři: Mu, Xianmin, Shi, Wei, Xu, Yue, Xu, Che, Zhao, Ting, Geng, Biao, Yang, Jing, Pan, Jinshun, Hu, Shi, Zhang, Chen, Zhang, Juan, Wang, Chao, Shen, Jiajia, Che, Yin, Liu, Zheng, Lv, Yuanfang, Wen, Hao, You, Qiang
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
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Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927648/
https://ncbi.nlm.nih.gov/pubmed/29468929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2018.1444305
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