Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation

Altered cellular metabolism is now generally acknowledged as a hallmark of cancer cells, the resultant abnormal oncometabolites cause both metabolic and nonmetabolic dysregulation and potential transformation to malignancy. A subset of cancers have been found to be associated with mutations in succi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Mu, Xianmin, Zhao, Ting, Xu, Che, Shi, Wei, Geng, Biao, Shen, Jiajia, Zhang, Chen, Pan, Jinshun, Yang, Jing, Hu, Shi, Lv, Yuanfang, Wen, Hao, You, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355086/
https://ncbi.nlm.nih.gov/pubmed/28061458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14485
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