PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway

BACKGROUND: Protein kinase N2 (PKN2) is a PKC-related serine/threonine-protein kinase. PKN2 is required for tumor cell migration, invasion and apoptosis. However, the functional role of PKN2 in regulating tumor associated macrophages (TAMs) polarization in colon cancer has never been reported. METHO...

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Опубликовано в: :Mol Cancer
Главные авторы: Cheng, Yang, Zhu, Yun, Xu, Jiajia, Yang, Min, Chen, Peiyu, Xu, Wanfu, Zhao, Junhong, Geng, Lanlan, Gong, Sitang
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784528/
https://ncbi.nlm.nih.gov/pubmed/29368606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-017-0747-z
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