Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching

INTRODUCTION: Current treatment with vasodilators for pulmonary hypertension associated with respiratory diseases is limited by their inhibitory effect on hypoxic pulmonary vasoconstriction (HPV) and uncoupling effects on ventilation-perfusion (V’/Q’). Hypoxia is also a well-known modulator of the n...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chamorro, Virginia, Morales-Cano, Daniel, Milara, Javier, Barreira, Bianca, Moreno, Laura, Callejo, María, Mondejar-Parreño, Gema, Esquivel-Ruiz, Sergio, Cortijo, Julio, Cogolludo, Ángel, Barberá, Joan A., Perez-Vizcaino, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5783366/
https://ncbi.nlm.nih.gov/pubmed/29364918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0191239
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