Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Elevated expression of the Zinc finger E-box binding homeobox transcription factor-2 (ZEB2) is correlated with poor prognosis and patient outcome in a variety of human cancer subtypes. Using a conditional gain-of-function mouse model, we recently demonstrated that ZEB2 is an oncogenic driver of imma...

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Xehetasun bibliografikoak
Argitaratua izan da:Blood
Egile Nagusiak: Goossens, Steven, Peirs, Sofie, Van Loocke, Wouter, Wang, Jueqiong, Takawy, Mina, Matthijssens, Filip, Sonderegger, Stefan E., Haigh, Katharina, Nguyen, Thao, Vandamme, Niels, Costa, Magdaline, Carmichael, Catherine, Van Nieuwerburgh, Filip, Deforce, Dieter, Kleifeld, Oded, Curtis, David J., Berx, Geert, Van Vlierberghe, Pieter, Haigh, Jody J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5783288/
https://ncbi.nlm.nih.gov/pubmed/28069602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-06-721191
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