Simvastatin attenuated rat thoracic aorta remodeling by decreasing ROCK2-mediated CyPA secretion and CD147-ERK1/2-cyclin pathway

Reactive oxygen species-induced cyclophilin A (CyPA) release from vascular smooth muscle cells (VSMCs) may be inhibited by simvastatin in vitro. The present study aimed to further examine the effect of simvastatin on serum CyPA levels and the basigin (CD147)-extracellular signal-regulated kinase (ER...

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Detalhes bibliográficos
Publicado no:Mol Med Rep
Main Authors: Tang, Fu-Cai, Wang, Hong-Yan, Ma, Ming-Ming, Guan, Tian-Wang, Pan, Long, Yao, Dun-Chen, Chen, Ya-Lan, Li, Sheng-Jie, Yang, Hang, Zhu, Xiao-Qin, Tu, Yong-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779895/
https://ncbi.nlm.nih.gov/pubmed/28983618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.7640
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