Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics

BACKGROUND: Although hydrochlorothiazide (HCTZ) is a well‐established first‐line antihypertensive in the United States, <50% of HCTZ treated patients achieve blood pressure (BP) control. Thus, identifying biomarkers that could predict the BP response to HCTZ is critically important. In this study...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Shahin, Mohamed H., Gong, Yan, Frye, Reginald F., Rotroff, Daniel M., Beitelshees, Amber L., Baillie, Rebecca A., Chapman, Arlene B., Gums, John G., Turner, Stephen T., Boerwinkle, Eric, Motsinger‐Reif, Alison, Fiehn, Oliver, Cooper‐DeHoff, Rhonda M., Han, Xianlin, Kaddurah‐Daouk, Rima, Johnson, Julie A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778957/
https://ncbi.nlm.nih.gov/pubmed/29288159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.006656
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