A GENETIC RESPONSE SCORE FOR HYDROCHLOROTHIAZIDE USE: INSIGHTS FROM GENOMICS AND METABOLOMICS INTEGRATION

Hydrochlorothiazide (HCTZ) is among the most commonly prescribed antihypertensives, yet <50% of HCTZ treated patients achieve blood pressure (BP) control. Herein, we integrated metabolomic and genomic profiles of HCTZ treated patients to identify novel genetic markers associated with HCTZ BP resp...

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發表在:Hypertension
Main Authors: Shahin, Mohamed H., Gong, Yan, McDonough, Caitrin W., Rotroff, Daniel M., Beitelshees, Amber L, Garrett, Timothy J., Gums, John G., Motsinger-Reif, Alison, Chapman, Arlene B., Turner, Stephen T., Boerwinkle, Eric, Frye, Reginald F., Fiehn, Oliver, Cooper-DeHoff, Rhonda M., Kaddurah-Daouk, Rima, Johnson, Julie A.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4982802/
https://ncbi.nlm.nih.gov/pubmed/27381900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.116.07328
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