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A Highly Durable RNAi Therapeutic Inhibitor of PCSK9
BACKGROUND: Inclisiran (ALN-PCSsc) is a long-acting RNA interference (RNAi) therapeutic agent that inhibits the synthesis of proprotein convertase subtilisin–kexin type 9 (PCSK9), a target for the lowering of low-density lipoprotein (LDL) cholesterol. METHODS: In this phase 1 trial, we randomly assi...
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| Publicado en: | N Engl J Med |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5778873/ https://ncbi.nlm.nih.gov/pubmed/27959715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1609243 |
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