Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

BACKGROUND: Mutations in LRRK2 are a common genetic cause of Parkinson’s disease (PD). LRRK2 interacts with and phosphorylates a subset of Rab proteins including Rab8a, a protein which has been implicated in various centrosome-related events. However, the cellular consequences of such phosphorylatio...

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Publicat a:Mol Neurodegener
Autors principals: Madero-Pérez, Jesús, Fdez, Elena, Fernández, Belén, Lara Ordóñez, Antonio J., Blanca Ramírez, Marian, Gómez-Suaga, Patricia, Waschbüsch, Dieter, Lobbestael, Evy, Baekelandt, Veerle, Nairn, Angus C., Ruiz-Martínez, Javier, Aiastui, Ana, López de Munain, Adolfo, Lis, Pawel, Comptdaer, Thomas, Taymans, Jean-Marc, Chartier-Harlin, Marie-Christine, Beilina, Alexandria, Gonnelli, Adriano, Cookson, Mark R., Greggio, Elisa, Hilfiker, Sabine
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778812/
https://ncbi.nlm.nih.gov/pubmed/29357897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0235-y
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