Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria

Accuracy of protein synthesis is enabled by the selection of amino acids for tRNA charging by aminoacyl-tRNA synthetases (ARSs), and further enhanced by the proofreading functions of some of these enzymes for eliminating tRNAs mischarged with noncognate amino acids. Mouse models of editing-defective...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Hilander, Taru, Zhou, Xiao-Long, Konovalova, Svetlana, Zhang, Fu-Ping, Euro, Liliya, Chilov, Dmitri, Poutanen, Matti, Chihade, Joseph, Wang, En-Duo, Tyynismaa, Henna
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5778596/
https://ncbi.nlm.nih.gov/pubmed/29228266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1231
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