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Mixing and matching mitochondrial aminoacyl synthetases and their tRNAs: a new way to treat respiratory chain disorders?

Mutations in mitochondrial DNA are an important cause of human disease and from a therapeutic standpoint, these disorders are currently untreatable. New studies now show that a non-cognate mitochondrial aminoacyl tRNA synthetase can overcome the respiratory defect caused by an mt-tRNA mutation and t...

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Autori principali: Tyynismaa, Henna, Schon, Eric A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927951/
https://ncbi.nlm.nih.gov/pubmed/24473201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201303586
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