Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children, total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar spine (LS) and femoral neck (FN) is used to diagnose osteoporosis. To date, genetic variants in more than 60 loci have been...

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Detalhes bibliográficos
Publicado no:Am J Hum Genet
Main Authors: Medina-Gomez, Carolina, Kemp, John P., Trajanoska, Katerina, Luan, Jian’an, Chesi, Alessandra, Ahluwalia, Tarunveer S., Mook-Kanamori, Dennis O., Ham, Annelies, Hartwig, Fernando P., Evans, Daniel S., Joro, Raimo, Nedeljkovic, Ivana, Zheng, Hou-Feng, Zhu, Kun, Atalay, Mustafa, Liu, Ching-Ti, Nethander, Maria, Broer, Linda, Porleifsson, Gudmar, Mullin, Benjamin H., Handelman, Samuel K., Nalls, Mike A., Jessen, Leon E., Heppe, Denise H.M., Richards, J. Brent, Wang, Carol, Chawes, Bo, Schraut, Katharina E., Amin, Najaf, Wareham, Nick, Karasik, David, Van der Velde, Nathalie, Ikram, M. Arfan, Zemel, Babette S., Zhou, Yanhua, Carlsson, Christian J., Liu, Yongmei, McGuigan, Fiona E., Boer, Cindy G., Bønnelykke, Klaus, Ralston, Stuart H., Robbins, John A., Walsh, John P., Zillikens, M. Carola, Langenberg, Claudia, Li-Gao, Ruifang, Williams, Frances M.K., Harris, Tamara B., Akesson, Kristina, Jackson, Rebecca D., Sigurdsson, Gunnar, den Heijer, Martin, van der Eerden, Bram C.J., van de Peppel, Jeroen, Spector, Timothy D., Pennell, Craig, Horta, Bernardo L., Felix, Janine F., Zhao, Jing Hua, Wilson, Scott G., de Mutsert, Renée, Bisgaard, Hans, Styrkársdóttir, Unnur, Jaddoe, Vincent W., Orwoll, Eric, Lakka, Timo A., Scott, Robert, Grant, Struan F.A., Lorentzon, Mattias, van Duijn, Cornelia M., Wilson, James F., Stefansson, Kari, Psaty, Bruce M., Kiel, Douglas P., Ohlsson, Claes, Ntzani, Evangelia, van Wijnen, Andre J., Forgetta, Vincenzo, Ghanbari, Mohsen, Logan, John G., Williams, Graham R., Bassett, J.H. Duncan, Croucher, Peter I., Evangelou, Evangelos, Uitterlinden, Andre G., Ackert-Bicknell, Cheryl L., Tobias, Jonathan H., Evans, David M., Rivadeneira, Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777980/
https://ncbi.nlm.nih.gov/pubmed/29304378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2017.12.005
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