Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway

Osteoporosis is a common skeletal disorder characterized by low bone mass leading to increased bone fragility and fracture susceptibility. In this study, we have identified pathways that stimulate differentiation of bone forming osteoblasts from human mesenchymal stromal cells (hMSCs). Gene expressi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Brum, Andrea M., van de Peppel, Jeroen, van der Leije, Cindy S., Schreuders-Koedam, Marijke, Eijken, Marco, van der Eerden, Bram C. J., van Leeuwen, Johannes P. T. M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611615/
https://ncbi.nlm.nih.gov/pubmed/26420877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501597112
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