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Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins
There are many factors that can influence the pharmacokinetics (PK) of a mAb or Fc-fusion molecule with the primary determinant being FcRn-mediated recycling. Through Fab or Fc engineering, IgG-FcRn interaction can be used to generate a variety of therapeutic antibodies with significantly enhanced h...
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| Published in: | Protein Cell |
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| Main Author: | |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Higher Education Press
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5777971/ https://ncbi.nlm.nih.gov/pubmed/28421387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-017-0408-4 |
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