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Pharmacokinetic properties of IgG and various Fc fusion proteins in mice
Fusion to an IgG Fc region is an established strategy to extend the half-life of therapeutic proteins. Most Fc fusion proteins, however, do not achieve the long half-life of IgGs. Based on findings that scFv-Fc fusion proteins exhibit a shorter half-life than the corresponding IgG molecules, we perf...
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| Publicado no: | MAbs |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4966510/ https://ncbi.nlm.nih.gov/pubmed/26514880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1113360 |
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