Genetic variation in the NEIL2 DNA glycosylase gene is associated with oxidative DNA damage in BRCA2 mutation carriers

In this report, we have tried to gain molecular insight into a single nucleotide polymorphism (SNP) in the NEIL2 gene previously identified as “cancer risk modifier” for BRCA2 mutation carriers. To that end, we studied the role of this SNP (rs804271) on NEIL2 transcriptional regulation, oxidative DN...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Benítez-Buelga, Carlos, Baquero, Juan Miguel, Vaclova, Tereza, Fernández, Victoria, Martín, Paloma, Inglada-Perez, Lucia, Urioste, Miguel, Osorio, Ana, Benítez, Javier
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777719/
https://ncbi.nlm.nih.gov/pubmed/29383107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22638
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