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Genetic variation in the NEIL2 DNA glycosylase gene is associated with oxidative DNA damage in BRCA2 mutation carriers

In this report, we have tried to gain molecular insight into a single nucleotide polymorphism (SNP) in the NEIL2 gene previously identified as “cancer risk modifier” for BRCA2 mutation carriers. To that end, we studied the role of this SNP (rs804271) on NEIL2 transcriptional regulation, oxidative DN...

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Publicat a:Oncotarget
Autors principals: Benítez-Buelga, Carlos, Baquero, Juan Miguel, Vaclova, Tereza, Fernández, Victoria, Martín, Paloma, Inglada-Perez, Lucia, Urioste, Miguel, Osorio, Ana, Benítez, Javier
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777719/
https://ncbi.nlm.nih.gov/pubmed/29383107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22638
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