Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization

BACKGROUND: Glioblastoma (GBM) is almost invariably fatal due to failure of standard therapy. The relapse of GBM following surgery, radiation, and systemic temozolomide (TMZ) is attributed to the ability of glioma stem cells (GSCs) to survive, evolve, and repopulate the tumor mass, events on which t...

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Publicat a:Neuro Oncol
Autors principals: Garnier, Delphine, Meehan, Brian, Kislinger, Thomas, Daniel, Paul, Sinha, Ankit, Abdulkarim, Bassam, Nakano, Ichiro, Rak, Janusz
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Basic and Translational Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777501/
https://ncbi.nlm.nih.gov/pubmed/29016925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox142
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