Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization

BACKGROUND: Glioblastoma (GBM) is almost invariably fatal due to failure of standard therapy. The relapse of GBM following surgery, radiation, and systemic temozolomide (TMZ) is attributed to the ability of glioma stem cells (GSCs) to survive, evolve, and repopulate the tumor mass, events on which t...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Garnier, Delphine, Meehan, Brian, Kislinger, Thomas, Daniel, Paul, Sinha, Ankit, Abdulkarim, Bassam, Nakano, Ichiro, Rak, Janusz
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777501/
https://ncbi.nlm.nih.gov/pubmed/29016925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox142
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