Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization

BACKGROUND: Glioblastoma (GBM) is almost invariably fatal due to failure of standard therapy. The relapse of GBM following surgery, radiation, and systemic temozolomide (TMZ) is attributed to the ability of glioma stem cells (GSCs) to survive, evolve, and repopulate the tumor mass, events on which t...

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Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: Garnier, Delphine, Meehan, Brian, Kislinger, Thomas, Daniel, Paul, Sinha, Ankit, Abdulkarim, Bassam, Nakano, Ichiro, Rak, Janusz
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2018
Aiheet:
Basic and Translational Investigations
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777501/
https://ncbi.nlm.nih.gov/pubmed/29016925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox142
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