Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization

BACKGROUND: Glioblastoma (GBM) is almost invariably fatal due to failure of standard therapy. The relapse of GBM following surgery, radiation, and systemic temozolomide (TMZ) is attributed to the ability of glioma stem cells (GSCs) to survive, evolve, and repopulate the tumor mass, events on which t...

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Vydáno v:Neuro Oncol
Hlavní autoři: Garnier, Delphine, Meehan, Brian, Kislinger, Thomas, Daniel, Paul, Sinha, Ankit, Abdulkarim, Bassam, Nakano, Ichiro, Rak, Janusz
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777501/
https://ncbi.nlm.nih.gov/pubmed/29016925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox142
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