Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function

Sustained energy starvation leads to activation of AMP-activated protein kinase (AMPK), which coordinates energy status with numerous cellular processes including metabolism, protein synthesis, and autophagy. Here, we report that AMPK phosphorylates the histone methyltransferase EZH2 at T311 to disr...

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Publicat a:Mol Cell
Autors principals: Wan, Lixin, Xu, Kexin, Wei, Yongkun, Zhang, Jinfang, Han, Tao, Fry, Christopher, Zhang, Zhao, Wang, Yao Vickie, Huang, Liyu, Yuan, Min, Xia, Weiya, Chang, Wei-Chao, Huang, Wen-Chien, Liu, Chien-Liang, Chang, Yuan-Ching, Liu, Jinsong, Wu, Yun, Jin, Victor X, Dai, Xiangpeng, Guo, Jianfeng, Liu, Jia, Jiang, Shulong, Li, Jin, Asara, John M., Brown, Myles, Hung, Mien-Chie, Wei, Wenyi
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777296/
https://ncbi.nlm.nih.gov/pubmed/29351847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.12.024
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