Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function

Sustained energy starvation leads to activation of AMP-activated protein kinase (AMPK), which coordinates energy status with numerous cellular processes including metabolism, protein synthesis, and autophagy. Here, we report that AMPK phosphorylates the histone methyltransferase EZH2 at T311 to disr...

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Publicado no:Mol Cell
Main Authors: Wan, Lixin, Xu, Kexin, Wei, Yongkun, Zhang, Jinfang, Han, Tao, Fry, Christopher, Zhang, Zhao, Wang, Yao Vickie, Huang, Liyu, Yuan, Min, Xia, Weiya, Chang, Wei-Chao, Huang, Wen-Chien, Liu, Chien-Liang, Chang, Yuan-Ching, Liu, Jinsong, Wu, Yun, Jin, Victor X, Dai, Xiangpeng, Guo, Jianfeng, Liu, Jia, Jiang, Shulong, Li, Jin, Asara, John M., Brown, Myles, Hung, Mien-Chie, Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777296/
https://ncbi.nlm.nih.gov/pubmed/29351847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.12.024
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