Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis

Acute pancreatitis is a complex disorder involving both premature intracellular protease activation and inflammatory cell invasion. An initiating event is the intracellular activation of trypsinogen by cathepsin B (CTSB), which can be induced directly via G protein–coupled receptors on acinar cells...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Aghdassi, Ali A., John, Daniel S., Sendler, Matthias, Weiss, F. Ulrich, Reinheckel, Thomas, Mayerle, Julia, Lerch, Markus M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777244/
https://ncbi.nlm.nih.gov/pubmed/29229780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.814772
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares