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Evaluating Metabolite-Related DNA Oxidation and Adduct Damage from Aryl Amines Using a Microfluidic ECL Array
Damage to DNA from the metabolites of drugs and pollutants constitutes a major human toxicity pathway known as genotoxicity. Metabolites can react with metal ions and NADPH to oxidize DNA or participate in S(N)2 reactions to form covalently linked adducts with DNA bases. Guanines are the main DNA ox...
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| Publicado no: | Anal Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5777145/ https://ncbi.nlm.nih.gov/pubmed/29083162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.7b03528 |
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