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Electrochemiluminescent Array to Detect Oxidative Damage in ds-DNA Using [Os(bpy)(2)(phen-benz-COOH)](2+)/Nafion/Graphene Films
Reactive oxygen species (ROS) oxidize guanosines in DNA to form 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG), a biomarker for oxidative stress. Herein we describe a novel 64-microwell electrochemiluminescent (ECL) array enabling sensitive multiplexed detection of 8-oxodG in ds-DNA without hydrolysis...
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| Publié dans: | ACS Sens |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4847550/ https://ncbi.nlm.nih.gov/pubmed/27135053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssensors.5b00189 |
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