Electrochemiluminescent Array to Detect Oxidative Damage in ds-DNA Using [Os(bpy)(2)(phen-benz-COOH)](2+)/Nafion/Graphene Films

Reactive oxygen species (ROS) oxidize guanosines in DNA to form 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG), a biomarker for oxidative stress. Herein we describe a novel 64-microwell electrochemiluminescent (ECL) array enabling sensitive multiplexed detection of 8-oxodG in ds-DNA without hydrolysis...

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Bibliographic Details
Published in:ACS Sens
Main Authors: Bist, Itti, Song, Boya, Mosa, Islam M., Keyes, Tia E., Martin, Aaron, Forster, Robert J., Rusling, James F.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847550/
https://ncbi.nlm.nih.gov/pubmed/27135053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssensors.5b00189
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