Inactivation of NMDA Receptors in the Ventral Tegmental Area during Cocaine Self-Administration Prevents GluA1 Upregulation but with Paradoxical Increases in Cocaine-Seeking Behavior

Cocaine self-administration increases expression of GluA1 subunits in ventral tegmental area (VTA) dopamine neurons, which subsequently enhance the motivation for cocaine. This increase in GluA1 may be dependent on concomitant NMDA receptor (NMDAR) activation during self-administration, similar to c...

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Publicado en:J Neurosci
Main Authors: Guzman, Daniel, Carreira, Maria B., Friedman, Allyson K., Adachi, Megumi, Neve, Rachael L., Monteggia, Lisa M., Han, Ming-Hu, Cowan, Christopher W., Self, David W.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2018
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777111/
https://ncbi.nlm.nih.gov/pubmed/29196318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2828-16.2017
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